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- Korean Red Giseng (Panax ginseng)
- Erectile Dysfunction
| Date: 11-14-2008 | HC# 100581-364 |
Re: Korean Red Ginseng May Aid in Erectile Dysfunction, but Better Quality Trials are Needed
Jang D-J, Lee MS, Shin B-C, Lee Y-C, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. October 2008;66(4): 444-450.
Erectile dysfunction affects 30-50% of men over the age of
40. Current medical interventions for the management of erectile dysfunction
include drugs, intrapenile therapies, and penile prosthetic implants. Korean
red ginseng (Panax ginseng) is the
steamed and dried roots of plants that are harvested six years after planting.
One of the popular uses of red ginseng is the enhancement of sexual function. Few
clinical trials have evaluated the effect of red ginseng on erectile
dysfunction, and recent reviews of erectile dysfunction therapies did not
include studies published in languages other than English. The purpose of this
systematic review was to critically evaluate the evidence from all randomized
controlled trials (RCTs) of red ginseng in men with erectile dysfunction.
Researchers at the Korea Institute of Oriental Medicine
searched electronic databases from their inception until January 2008. The
databases included MEDLINE, AMED (Allied and Complementary Medicine Database),
British Nursing Index, CINAHL (Cumulative Index to Nursing and Allied Health
Literature), EMBASE (Excerpta Medica Database), PsycInfo, The Cochrane Library,
six Korean medical databases, four Chinese medical databases, and three
Japanese medical databases. The researchers also manually searched relevant
journals and checked the references of all articles identified in the search.
The analysis included all articles that reported on a RCT in which human
subjects with any type of erectile dysfunction were treated with any type of
red ginseng, regardless of language of publication. Three independent reviewers
read, extracted, and rated each article.
The researchers identified 28 potentially relevant trials,
and 7 of these trials met the criteria for inclusion in the analysis. A total
of 363 men, ranging in age from 24 to 70 years, were studied in these 7 trials.
The duration of treatment with red ginseng ranged from 4 to 12 weeks. The doses
of red ginseng ranged from a daily total of 1800 mg to 3000 mg. Outcome
measures included scores on the International Index of Erectile Function, the
Watts sexual function questionnaire, global efficacy questions, and study-specific
structured interview questionnaires related to erectile function.
Six of the trials reported an improvement in erectile
function in subjects taking red ginseng compared to subjects taking placebo. A
meta-analysis of data from the seven trials suggests that red ginseng is
superior to placebo in improving erectile function (P < 0.0001). The
methodological quality of the trials was variable, ranging from scores of 1 to
5 on the Jadad scale. The majority of the articles failed to report the method
of randomization, the method of double-blinding, and details about subject
withdrawals and drop-outs. Other shortcomings included failure to report a
power calculation for statistical analysis and failure to report approval of
the study by a research ethics board.
The authors explain that this is the first systematic review
and meta-analysis of RCTs of the effectiveness of Korean red ginseng in men
with erectile dysfunction. They conclude that these trials provide evidence
suggesting such effectiveness. However, the number of trials that could be
included in the analysis, the total sample size, and the typical methodological
quality of the studies were too low to allow firm conclusions to be drawn. The
authors recommend that additional studies with better methodological quality
are needed to establish whether or not Korean red ginseng has a place in the
treatment of erectile dysfunction.
The American Botanical Council provides this review
as an educational service. By
providing this service, ABC does not warrant that the data is accurate and
correct, nor does distribution of the article constitute any endorsement of
the information contained or of the views of the authors.
ABC does not authorize the copying or use of the
original articles. Reproduction of
the reviews is allowed on a limited basis for students, colleagues,
employees and/or members. Other uses
and distribution require prior approval from ABC.
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—Heather
S. Oliff, PhD |